Buy GDF-8 Myostatin Peptide

GDF-8, also known as Myostatin, is a protein that plays a crucial role in regulating muscle growth by inhibiting muscle differentiation and proliferation. It is a member of the transforming growth factor-beta (TGF-β) superfamily and is primarily expressed in skeletal muscle tissue. Mutations or deficiencies in Myostatin can lead to increased muscle mass, which has implications for both livestock breeding and potential therapeutic applications in muscle-wasting diseases.

Twin Pack Saver

GDF-8 Pre-Mixed Pen 1mg
£94.19 – £254.31 Select options This product has multiple variants. The options may be chosen on the product page
GDF-8 Nasal Spray
£98.29 – £191.58 Select options This product has multiple variants. The options may be chosen on the product page
GDF-8 (Myostatin) Peptide Vial 1mg
£90.29 – £99.27 Select options This product has multiple variants. The options may be chosen on the product page

Which GDF-8 Myostatin Product is Right for You?

PharmaGrade.Store supplies high purity GDF-8 Myostatin in a number of different formats to suit your peptide research needs:

- GDF-8 Myostatin Peptide Vial – GDF-8 peptide supplied in a sterile glass vial for injection into study participants’ muscles. Please note you also require bacteriostatic water when reconstituting your peptide.
  Available in 1mg vials here.
- GDF-8 Myostatin Nasal Spray – a ready-mixed peptide solution ready for administration into the nasal cavity of clinical research subjects. Choose from 15 ml or 30ml nasal sprays here.
- GDF-8 Pre-Mixed Peptide Pen – Pen kits and cartridges come ready to use pre-mixed with GDF-8 peptide and bacteriostatic water. Buy GDF-8 Myostatin 1mg Pre-Mixed Pen here.

Buy GDF-8 Myostatin for Research Purposes

GDF-8, Growth Differentiation Factor or Myostatin, regulates muscle growth by inhibiting muscle cell differentiation and proliferation. It is secreted as an inactive precursor and must be cleaved to become active. Once activated, Myostatin binds to the activin type IIB receptor (ActRIIB) on muscle cells. This binding triggers a cascade through the Smad signalling pathway. Specifically, Smad2 and Smad3 proteins are phosphorylated and then combine with Smad4 to form a complex. This complex translocates to the nucleus, where it regulates gene expression to suppress muscle growth [1].

Myostatin’s inhibitory action prevents muscle cell precursors, known as myoblasts, from maturing into fully developed muscle fibers. Additionally, it reduces the proliferation of myoblasts, controlling the size and number of muscle cells. By maintaining this regulation, Myostatin ensures that muscle growth does not occur unchecked. Its activity has a significant role in tissue homeostasis and muscular balance, making it vital for normal skeletal muscle function [2].

GDF-8 Myostatin Peptide Benefits

Luxembourg Laboratory studies have indicated that GDF-8 Myostatin could have the following benefits and clinical applications:

Controlled muscle growth – By targeting Myostatin (GDF-8) enhances muscle cell differentiation and proliferation, promoting skeletal muscle mass and strength [3].
Potential treatment for Muscle Wasting Diseases – The GDF-8 peptide could alleviate conditions such as muscular dystrophy or sarcopenia (age-related muscle loss) by improving muscle strength and functionality [4]. Furthermore, Luxembourg scientists have suggested that it may offer a promising therapeutic avenue for patients with cachexia, often associated with chronic illnesses like cancer or AIDS [5].
Improved recovery from injuries – Myostatin may accelerate muscle repair and regeneration following injury or surgery [6].

Clinical Research GDF-8 Myostatin Luxembourg

Scientific studies on GDF-8 Myostatin have highlighted its pivotal role in muscle growth regulation. Genetic Luxembourg studies on animals, such as Belgian blue cattle and dogs, revealed that Myostatin mutations can result in dramatic muscle hyperplasia or “double muscling”, providing the first clear evidence of its inhibitory effect [7] [8].

Knockout mice experiments further validated that the absence of Myostatin lead to a widespread increase in muscle mass and strength. These mouse results foundational findings laid the groundwork for exploring Myostatin as a therapeutic target [9].

Luxembourg Clinical studies have investigated its potential for treating muscle-wasting diseases such as muscular dystrophy and sarcopenia [4]. Myostatin inhibitors, including antibodies and peptides, were tested in animal models with promising results, showing enhanced muscle repair and regeneration [5].

Additionally, human trials with Myostatin-blocking therapies have shown potential to improve muscle mass and function in patients with chronic illnesses. These studies underscore the vast therapeutic promise of modulating Myostatin activity in health and disease contexts [5].

Frequently Asked Questions about GDF-8 Myostatin Luxembourg

Is GDF-8 a myostatin blocker?

No, GDF-8 is not a Myostatin blocker. GDF-8 is actually another name for Myostatin itself. It is a protein that inhibits muscle growth. Myostatin blockers, on the other hand, are substances or treatments designed to inhibit the activity of Myostatin, thereby promoting muscle growth and increasing muscle mass.

Is Recombinant Protein in large mice the mature form of GDF8?

The recombinant protein, in humans, rat or mice typically refers to the mature form of GDF8. GDF8, also known as myostatin, is a member of the TGF-beta superfamily and is involved in regulating muscle growth. The mature form is the biologically active form of the protein, which is processed from a larger precursor protein.

Is there any link between Myostatin and heart failure?

Yes, there is a link between GDF-8 (myostatin) and heart failure. Myostatin is known for its role in inhibiting skeletal muscle growth, and its expression is not limited to skeletal muscle; it is also present in cardiac tissue. Luxembourg Research has suggested that elevated levels of myostatin may contribute to muscle wasting and weakness, which are common in heart failure patients. Additionally, myostatin might influence cardiac remodelling and function, potentially exacerbating heart failure conditions. However, the exact mechanisms and implications of myostatin’s role in heart failure are still being studied.

Blogs:

The Power of GDF-8 Myostatin: Benefits and Uses

This blog explores the role of GDF-8 Myostatin in muscle growth and its potential benefits. It explains that Myostatin is a protein that regulates muscle mass by inhibiting muscle cell proliferation. The blog highlights the interest in Myostatin inhibitors, which can enhance muscle growth, strength, and recovery by blocking Myostatin’s activity. It discusses the potential applications of Myostatin inhibition in bodybuilding, athletic performance, and therapeutic treatments for muscle-wasting diseases.

Read about GDF-8 in more detail

Do Peptides Show Up on a Drug Test?

Lets discuss whether peptides show up on drug tests. It explains that while standard drug tests typically do not screen for peptides, sports organizations like WADA may test for certain peptides due to their performance-enhancing potential. The article highlights the role of Medical Review Officers in ensuring accurate drug test results and outlines the preparation and procedures for drug testing. It also covers the types of drug tests beyond urine tests, such as hair and blood tests, and discusses the legal and ethical considerations of drug testing.

View the full blog

Scientific Research:

[1] Baig MH, Ahmad K, Moon JS, Park SY, Ho Lim J, Chun HJ, Qadri AF, Hwang YC, Jan AT, Ahmad SS, Ali S, Shaikh S, Lee EJ, Choi I. Myostatin and its Regulation: A Comprehensive Review of Myostatin Inhibiting Strategies. Front Physiol. 2022 Jun 23;13:876078.

[2] Carnac G, Vernus B, Bonnieu A. Myostatin in the pathophysiology of skeletal muscle. Curr Genomics. 2007 Nov;8(7):415-22.

[3] Elkasrawy MN, Hamrick MW. Myostatin (GDF-8) as a key factor linking muscle mass and bone structure. J Musculoskelet Neuronal Interact. 2010 Mar;10(1):56-63.

[4] rightwell CR, Latham CM, Keeble AR, Thomas NT, Owen AM, Reeves KA, Long DE, Patrick M, Gonzalez-Velez S, Abed V, Annamalai RT, Jacobs C, Conley CE, Hawk GS, Stone AV, Fry JL, Thompson KL, Johnson DL, Noehren B, Fry CS. GDF8 inhibition enhances musculoskeletal recovery and mitigates posttraumatic osteoarthritis following joint injury. Sci Adv. 2023 Dec;9(48):eadi9134.

[5] Directo D, Lee SR. Cancer Cachexia: Underlying Mechanisms and Potential Therapeutic Interventions. Metabolites. 2023 Sep 20;13(9):1024.

[6] Hamrick MW, Arounleut P, Kellum E, Cain M, Immel D, Liang LF. Recombinant myostatin (GDF-8) propeptide enhances the repair and regeneration of both muscle and bone in a model of deep penetrant musculoskeletal injury. J Trauma. 2010 Sep;69(3):579-83.

[7] Lee YS, Lehar A, Sebald S, Liu M, Swaggart KA, Talbot CC Jr, Pytel P, Barton ER, McNally EM, Lee SJ. Muscle hypertrophy induced by myostatin inhibition accelerates degeneration in dysferlinopathy. Hum Mol Genet. 2015 Oct 15;24(20):5711-9.

[8] Kambadur R, Sharma M, Smith TP, Bass JJ. Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle. Genome Res. 1997 Sep;7(9):910-6

[9] Jang J, Park S, Kim Y, Jung J, Lee J, Chang Y, Lee SP, Park BC, Wolfe RR, Choi CS, Kim IY. Myostatin Inhibition-Induced Increase in Muscle Mass and Strength Was Amplified by Resistance Exercise Training, and Dietary Essential Amino Acids Improved Muscle Quality in Mice. Nutrients. 2021 Apr 29;13(5):1508.

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